Medicinal gold compounds

Medicinal plants, a gold mine of anticancer compounds

Cancer is an umbrella term used to describe a variety of diseases in which cells start dividing abnormally. These cells then spread through blood and lymph system to invade other tissues of the body. There exist more than 100 different types of cancer. Depending upon the site of origin, cancer can be grouped as carcinoma (starting in the skin or tissue lining of internal organs), sarcoma (cance...

Introduction of Medicinal Chemistry & Heterocyclic Compounds

Medicinal Herb Compounds: High-speed Countercurrent Chromatography

San Francisco: W. Freeman Publishers. Miller BV and Lines R (1988) Recent advances in particle size measurement: a critical review. Critical Reviews in Analytical Chemistry 20(2): 75}116. Oglesby S Jr and Nichols GB (1978)Electrostatic Precipitation. New York: Marcel Dekker Inc. Provder T (ed.) (1998) Particle Size Distribution III, Assessment and Characterization.ACS Symposium Series 693, ACS....

Effect of two gold compounds on lysosomes.

The effect of two gold(I) compounds on stability of lysosomes in vitro was studied. Lysosomes from homogenates of rat kidney cortex were isolated by differential centrifugation. These lysosomes were incubated at 37 degrees C with widely varied concentrations of sodium aurothiomalate and sodium aurothiosulphate for 5, 35, and 65 minutes. Acid phosphatase activities were measured and used as an i...

Excited States of Gold(I) Compounds, Luminescence and Gold-Gold Bonding

It has long been established by Khan that the superoxide anion, O(2) (-), generates singlet oxygen, O(2) (1)Delta(g), during dismutation. Auranofin, gold-phosphine thiols, beta-Carotene, and metal-sulfur compounds can rapidly quench singlet O(2). The quenching of the O(2) (1)Delta(g), which exists at 7752 cm(-1) above the ground state triplet, may be due to the direct interaction of the singlet...